vitamin d binding protein as screening biomarker candidate for late-onset preeclampsia without intrauterine growth restriction during 16 week of gestation.

How to Manage Intrauterine Growth Restriction Associated with Severe Preeclampsia at 28-34 Weeks of Gestation?

Selcuk University, Meram Faculty of Medicine, Departments of Obstetrics and Gynecology1 and Pediatry2, Konya, Turkey Aim: To propose optimal management of intrauterine growth restriction (IUGR) cases associated with severe preeclampsia at 28-34 weeks of gestation. Methods: Two hundred pregnant women with severe preeclampsia associated with growth restricted fetuses were followed with doppler ve...

Successful intrauterine therapy for fetal goitrous hypothyroidism during late gestation.

We experienced a case of fetal goitrous hypothyroidism in an infant delivered by a 33-year-old woman receiving 300 mg/day of propylthiouracil (PTU) for hyperthyroidism due to Graves' disease. A large fetal goiter (maximum diameter, 60 mm) was detected by magnetic resonance imaging (MRI) at 36 weeks of gestation. Initial fetal blood sampling revealed hypothyroidism with a serum thyroid-stimulati...

TITLE: Nephrogenesis and the renal renin-angiotensin system in fetal sheep: effects of intrauterine growth restriction during late gestation AUTHORS:

Nephrogenesis and the renal renin-angiotensin system in fetal sheep: effects of intrauterine growth restriction during late gestation.

Previous studies have shown that intrauterine growth restriction (IUGR) can impair nephrogenesis, but uncertainties remain about the importance of the gestational timing of the insult and the effects on the renal renin-angiotensin system (RAS). We therefore hypothesized that induction of IUGR during late gestation alters the RAS, and this is associated with a decrease in nephron endowment. Our ...

Transthyretin as a novel candidate biomarker for preeclampsia

Preeclampsia (PE) is considered to be a potentially fatal complication during pregnancy. However, no effective laboratory assessment has been developed to enable early diagnosis and monitoring of PE. The present study aimed to identify differentially expressed transthyretin (TTR) during severe PE and evaluate TTR as a possible biomarker of this disease. TTR levels were determined in the differe...

Impaired vascular growth in late adolescence after intrauterine growth restriction.

BACKGROUND Abnormal blood flow in a fetus small for gestational age indicates true fetal intrauterine growth restriction (IUGR). We tested the hypothesis that IUGR with abnormal fetal blood flow is associated with long-term abnormal vascular morphology and function in adolescence. METHODS AND RESULTS In a prospective study, vascular mechanical properties of the common carotid artery (CCA), ab...